Principal Scientist - Vector Core Development

Hobson Prior are looking for a talented Principal Scientist - Vector Core Development to join a clinical-stage biotech organisation focused on AAV-based gene therapy targeting the liver. This position with help with ground-breaking research in AAV-based gene therapy aimed at developing the next generation of therapeutics.

Please note that to be considered for this role you must have the right to work in this location.

Job Responsibilities:

• Responsible to set up and manage AAV vectors inventories.
• Oversee vector core for research-grade AAV vectors and manage daily activities of the team in collaboration with senior leadership to meet research timelines and programme/corporate objectives.
• Build a highly efficient team capable of handling tight timelines and delivery of quality data.
• Accountable for virus production, purification, titration and QC.
• Coordinate AAV production needs with internal teams and manage supply-chain.
• Stay up to date in the viral vector purification/production field by exploring new technologies, including high-throughput platforms and concepts, to identify opportunities to increase vector productivity and quality for both discovery and preclinical operations.
• Communicate and work collaboratively with CROs to support vector needs in research.
• Contribute to a collaborative, creative, and rigorous culture of scientific discovery.
• To maintain accurate and detailed laboratory notes.
• Author and review technical materials, procedures, protocols, and reports.

Key Skills:

• Strong critical, scientific, and strategic thinking skills
• Excellent interpersonal skills with demonstrated ability to work collaboratively in cross-functional teams.
• Ability to manage significant resource demand efficiently prioritizing and communicating with stakeholders.
• Proficient in MS Office, Geneious (or similar DNA analysis software), DoE/statistics software (JMP, Prism, etc.).
• Well-organized and detailed-oriented with ability to juggle multiple tasks and work in a fast-paced environment.

Requirements:

• Ph.D. in Cell Biology, Molecular Biology, Virology, Biochemistry, Biophysics or related field with at 3+ years of experience, in the pharmaceutical industry or academic environment. MSc/MRes candidates with substantial experience also considered.
• You will have extensive experience in production of gene therapy vectors, particularly AAV, and operation and management of vector core facility.
• Expertise/knowledge in both upstream and downstream processes. Specific expertise in established methods to measure the quality and titre of purified AAV vector is a plus.
• Experience in managing and collaborating with CROs.
• Experience in developing SOPs and high throughput workflows.
• Experience in managing or supervising a team of scientists.
• Background and understanding of AAV biology as well as gene therapy are highly desirable.

Apply now:

If you are interested in learning more or applying to this exciting opportunity then please click "Apply" and upload a copy of your CV. Alternatively, for further details or to talk directly to a life sciences recruitment specialist directly, please select "Contact me" at the top of this page.

Hobson Prior is a leading life sciences recruiter focused on finding exceptional people and matching them with the finest positions across the globe. Hobson Prior is acting as an Employment Agency in relation to this vacancy.