Principal Scientist - Cell Line Development

Hobson Prior are looking for a Principal Scientist - Cell Line Development for an exciting opportunity to join a rapidly growing CMC group on a permanent basis in Oxford. You will be accountable for the development of fully traceable, regulatory compliant clonal stable cell lines and cell pools used to manufacture novel exosome therapeutics.

Job Responsibilities:

• Lead and grow a team of cell line development scientists as well as working 'hands-on' to deliver CLD and platform development activities.
• Work collaboratively with Research, Process Development and Quality to develop and establish new techniques and recommend alternative approaches and potential solutions to cell line issues.
• Develop and establish traceable and regulatory compliant optimised expression constructs the production of engineered manufacturing mammalian cell lines.
• Develop and establish an industry leading Cell Line Development capability for the production of engineered exosomes therapeutics (transient and stable transfections, pool and monoclonal clone generation, pre-master cell stock banks, in-vitro cell age stability studies, genetic characterisation).
• Develop and establish novel mammalian 'host' cell lines with attributes suitable for the production of engineered exosomes loaded with a wide range of therapeutic cargo's.
• Deliver cell line history and CLD documentation and reports ensuring appropriate quality of documentation, cell line segregation and materials traceability to support inclusion of data and information in regulatory filings.
• Deliver research cell lines suitable to support early non-clinical development.
• Ensure a healthy and safe working environment and compliance to GMO/ACDP requirements.

Key Skills:

• Ability to work independently and lead others.
• Good conceptual, analytical thinking, problem solving, and organisational skills.
• Ability to work in a high paced team environment, meet deadlines, and prioritise work from multiple projects.
• Strong interpersonal and communication skills with demonstrated ability to work within a team environment.

Requirements:

• PhD or BSc/MSc in Cell Biology, Molecular Biology, Biochemistry, Biotechnology, Food Science, Biological or a related field.
• Ability to balance multiple priorities and projects at the same time and be able to change priorities as needed by the business.
• At least 5+ years direct industrial laboratory experience in biologics and/or cell/viral product cell line development post PhD or 8+ years direct industrial laboratory experience as above post BSc/MSc.
• Experience in the development, optimisation and establishment of industrial expression vectors and derivation of mammalian cell line development platforms complaint with regulatory expectations.
• Knowledge and experience of general cell culture techniques, including transfection, selection, cloning, small scale production models and product expression.
• Background in cell and molecular biology, with experience in host cell engineering, cell culture process development, vector development, and/or development of novel analytical methods to aid in cell line generation.
• Familiarity with instruments commonly used in a cell line generation laboratory such as ViCell, Nutrient analysers, single cell derivation platforms, cell imagers.
• Understanding of the regulatory requirements on the quality of biotechnological/biological products and derivation and characterisation of cell substrates used for production of biotechnological/biological products.
• Leadership experience, ideally growing, leading, developing a cell line development team.

Apply now:

If you are interested in learning more or applying to this exciting opportunity, please complete the form below and attach a copy of your CV. Alternatively, for further details or to talk directly to a life sciences recruitment specialist, please request a call back at the top of this page.

Hobson Prior is a leading life sciences recruiter focused on finding exceptional people and matching them with the finest positions across the globe. Hobson Prior is acting as an Employment Agency in relation to this vacancy.