Director & Head of Drug Metabolism & Pharmacokinetics (DMPK)

Hobson Prior are currently looking for a Director & Head of Drug Metabolism & Pharmacokinetics to join a therapeutics company on a permanent basis located in Cambridge.

Please note that to be considered for this role you must have the right to work in this location.

Key Responsibilities:

• The ideal candidate will be responsible for defining and providing the DMPK strategy for multiple portfolio programmes to generate data packages to enable decision-making throughout lead optimisation and nomination of clinical candidates for IND/CTA-enabling studies and clinical entry.
• Developing strategic & project plans to make most efficient use of internal & external resources.
• Scientific leadership including project leadership, mentorship and development of scientists in the R&D team.
• Working in interdisciplinary teams to support research strategies and project goals. Identifying and working with external consultants to bring additional expertise to teams.
• Partnerships with external collaborators: identifying appropriate collaborators (CROs, academics or others), designing studies and interpreting outputs.
• Presenting plans and results internally, including at board level, and externally at international conferences.
• Contributing as part of the R&D leadership team to the wider development of the company's R&D strategy and portfolio.
• Designing project strategies & studies and interpreting data from in vitro & in vivo pharmacokinetic & metabolism studies as well as contributing to the design of PK/PD and efficacy studies to assess potential for clinical utility of lead molecules.
• Contributing to target selection, prioritisation and advancement discussions across portfolio.
• Working with clinical leaders and external experts to define target product profiles and generate data packages to support regulatory filings.
• Contributing to design of appropriate toxicology studies to assess project/compound progress ability.
• Contributing to writing of regulatory submission documentation.

Requirements:

• Ph.D in Biology, Pharmacology or a related discipline or a BSc/MSc degree with significant relevant pharma/biotech/CRO drug discovery experience. At least 5 years experience contributing DMPK expertise to successful drug discovery projects across phases from lead optimisation to clinical entry in a pharma, biotech or CRO environment.
• A deep understanding of contemporary small molecule drug discovery and development.
• Experience of contributing to company or business unit R&D strategy through creative planning and prioritisation of opportunities.
• Evidence of significant scientific productivity and impact through your own personal leadership of projects to key milestones including candidate selection and clinical entry.
• Extensive experience of design and development of suitable strategies to assess DMPK, PK/PD and developability of lead molecules. Interpretation of results including appropriate quantitative and statistical aspects.
• Highly scientifically creative and flexible as evidenced by successful delivery of multiple projects including "non-standard" projects.
• Good network & relationships with a wide range of CROs and other external collaborators to identify and access all of the systems and models required for data package generation.
• Outstanding scientific reputation as evidenced by publication and presentations.
• Strong interpersonal communication to both senior leadership and project/matrix teams.
• Evidence of successful leadership of teams to achieve significant project milestones.
• A hands-on approach to personally leading project and R&D success.
• Experience of working in fast-moving drug discovery environment, contributing to successful delivery of multiple projects in parallel.

Apply now:

If you are interested in learning more or applying to this exciting opportunity then please click "Apply" and upload a copy of your CV. Alternatively, for further details or to talk directly to a life sciences recruitment specialist directly, please select "Contact me" at the top of this page.

Hobson Prior is a leading life sciences recruiter focused on finding exceptional people and matching them with the finest positions across the globe. Hobson Prior is acting as an Employment Agency in relation to this vacancy.