Hobson Prior are currently working with a top biotech organisation who are focused on the treatment of solid cancers. Our client is looking for a Protein Chemist to join them on a permanent basis in Stevenage.

Job Responsibilities:

• You will uphold a high level of knowledge and skills in technical R&D areas related to Antibodies and Antibody-drug conjugates.
• Carry out laboratory R&D using Good Laboratory and Safety Practice.
• You will communicate technical knowledge both internally and externally, with staff and collaborators at internal meetings, presentations and conferences.
• Produce robust and accurate experimental reports, have organised electronic data management, prepare risk assessments, SOPs, batch reports and internal/external study reports as required.
• Attend internal and external meetings as required, presenting data using PowerPoint.
• Communicate with contract research organisations and participate in multiple projects as required.
• Follow existing SOPs to perform, screen and document antibody-small molecule conjugations using a range of linker chemistries, small molecules and excipients.
• Develop new methods for antibody-small molecule conjugation.
• Perform post-conjugation purification using a range of chromatographic tools (e.g. AKTA, HPLC, SEC, TFF).
• Develop, validate and use analytical methods to study ADCs using HPLC (RP, SEC, HIC, IEX).
• Coordinate with protein production scientists and synthetic chemists in order to supply samples that will supply others for invitro and in vivo studies
• Communicate with affiliated scientists (internal and external) that will be carrying out LC-MS analysis in vitro and preclinical in vivo modelling, antibody/ADC pharmacokinetics and pharmacodynamics.
• Willing to temporarily change roles to fulfil project deadlines, e.g. step in to help with medicinal chemistry synthesis and processing.

Key Skills:

• Demonstrate a high level of attention to detail and work to a high standard.
• Be resilient to pressure and flexible to demands of work and deadlines.

Requirements:

• You must have a strong chemistry/protein chemistry background.
• Willing to work to tight deadlines, receiving samples from other members of the team last in the chain.
• Basic practical biochemistry techniques essential such as handling proteins, buffer exchange, SDS PAGE, quantitation, etc.

Apply now:

If you are interested in learning more or applying to this exciting opportunity, please complete the form below and attach a copy of your CV. Alternatively, for further details or to talk directly to a life sciences recruitment specialist, please request a call back at the top of this page.

Hobson Prior is a leading life sciences recruiter focused on finding exceptional people and matching them with the finest positions across the globe. Hobson Prior is acting as an Employment Agency in relation to this vacancy.