Hobson Prior are looking for a Principal Scientist - Fibrotic Remodelling to join a leading biopharmaceutical company on an 18-month contract basis in Slough. This position will assist with early biomarker development in biofluids and the second to undertake mechanism of action studies in the development of anti-fibrotic therapies.

Job Responsibilities:

• Working in multiple project teams to develop and apply ligand-based assays in biofluids and tissues to support biomarker development.
• Develop and apply complex primary human cell models of disease that reflect the biology of the target and be used to understand mechanisms, pathways and therapeutic intervention.
• Using a range of scientific competencies, develop relevant assays for: screening, function; mechanism; target validation as appropriate.
• Ability to analyse, interrogate data and troubleshoot technical issues.
• Using excellent communication and team working abilities, disseminate high quality data for wider review in reporting and visualisation environments.
• Present experimental data at cross-functional meetings and external conferences.
• Maintain compliant procedures by completing training modules and maintaining experimental records.
• Aim to publish work in high impact scientific journals and in patents.
• Display awareness of published literature and externally available platforms and technologies.
• Depending upon experience, contribute to the development and incorporation of new technologies and/or techniques and mentoring/training of other scientists.
• Comply with HTA regulations, ensuring that relevant training is up-to-date and that you have read and understood the HTA Policies and Procedures Manual.

Requirements:

• PhD or equivalent.
• Significant expertise in the running and development of ligand-based assays (eg. ELISA, MSD, Luminex) in biological fluids. The ability to transfer these skills to colleagues both internally and externally (i.e. collaborators).
• Working knowledge of biomarker discovery and development including an understanding of required CV and QC needs.
• History of successful application of primary human cell culture assays to model disease pathology both in a 2D and 3D environment.
• Application of immunofluorescent endpoints in culture systems especially using multiplexed approaches.
• Some experience in the area of fibrotic remodeling, especially in the kidney would be beneficial.

Apply now:

If you are interested in learning more or applying to this exciting opportunity, please complete the form below and attach a copy of your CV. Alternatively, for further details or to talk directly to a life sciences recruitment specialist, please request a call back at the top of this page.

Hobson Prior is a leading life sciences recruiter focused on finding exceptional people and matching them with the finest positions across the globe. Hobson Prior is acting as an Employment Agency in relation to this vacancy.